利用质谱学碎片化模式,在可疑样本中加速选和结构阐明新的埃托米达类型
Yilei Fan1, Xianxin Chen2, Hao Wu3
1Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Department of Criminal Science and Technology, Zhejiang Police College, Hangzhou 310053, PR China; College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou 310053, PR China.
法医实验室现在可以快速识别使用质量碎片化模式的新型etomidate类似物. 这种方法有助于区分结构变化和确认新的精神活性物质.
科学领域:
- 法医化学 法医化学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 埃托米达类类似物是具有快速变化的结构的精神活性物质.
- 它们的结构多样性给法医分析和鉴定带来了挑战.
- 快速而准确的识别方法对于法医实验室至关重要.
研究的目的:
- 调查埃托米达类同类的结构演变规则.
- 开发一种非向查和结构识别方法,用于埃托米达类同类物.
- 应用质量碎片化模式,以快速选和确认.
主要方法:
- 气色谱-四极点飞行时间质谱 (GC-QTOF/MS).
- 液体染色学-Q-轨道仪质谱/质谱 (LC-Q-轨道仪MS/MS).
- 电子喷射电离-质谱/质谱 (ESI-MS/MS) 和电子电离质谱 (EI-MS) 用于碎片化模式分析.
主要成果:
- 在可疑样本中发现了8种埃托米达类型.
- 确定了关键质量碎片 (ESI-MS/MS中的e,f离子;EI-MS中的a,b离子;ESI-MS/MS中的d,e,f离子) 用于结构阐明.
- 通过核磁共振 (NMR) 证实了四种新型类似物 (丁胺,sec-丁胺,4F-丁胺,CF3-丁胺).
结论:
- 质量碎片化模式为非有针对性的识别和识别埃托米达类相应物提供了基础.
- 这项研究建立了一个强大的方法来推断和证实在法医环境中新的埃托米达类型.
- 这项研究支持法医实验室应对新兴设计药物带来的挑战.
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