Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

158
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
158

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Analysis of HERV-K (HML2) Expression in Colorectal Cancer Samples.

Epigenomes·2026
Same author

The Efficacy of Electronic Health Record-Based Artificial Intelligence Models for Early Detection of Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Cancers·2026
Same author

Neoantigen-Driven Immunotherapy in Triple-Negative Breast Cancer: Emerging Strategies and Clinical Potential.

Biomedicines·2025
Same author

Development of Ex Vivo Analysis for Examining Cell Composition, Immunological Landscape, Tumor and Immune Related Markers in Non-Small-Cell Lung Cancer.

Cancers·2024
Same author

Surgery in Metastatic Seminoma: Negative Trial Should Be Treated as Negative.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same author

Real-World Experience with Targeted Therapy in BRAF Mutant Advanced Melanoma Patients: Results from a Multicenter Retrospective Observational Study Advanced Melanoma in Russia (Experience) (ADMIRE).

Cancers·2021

相关实验视频

Updated: Sep 19, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.8K

在MOTION研究中进行了全面的分子分析.

Olesya A Kuznetsova1, Maxim V Ivanov2, Alexandra A Lebedeva3

  • 1Department of Chemotherapy, Federal State Budgetary Institution (N.N. Blokhin National Medical Research Center of Oncology) of the Ministry of Health of the Russian Federation, Moscow 115478, Russia; OncoAtlas LCC, Moscow 119049, Russia.

Cancer genetics
|June 18, 2025
PubMed
概括

综合分子分析 (CMP) 和分子匹配疗法 (MMT) 改善了晚期固体瘤的结果. 毫米疗法显示出更好的反应率和无进展生存率,即使对基因组更少可操作的改变.

关键词:
进行全面的分子分析.基因的改变 基因的改变个性化瘤学 个性化瘤学固体瘤是一种固体瘤.

更多相关视频

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

19.5K
High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs
07:27

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs

Published on: August 3, 2011

20.7K

相关实验视频

Last Updated: Sep 19, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.8K
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

19.5K
High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs
07:27

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs

Published on: August 3, 2011

20.7K

科学领域:

  • 在瘤学瘤学.
  • 基因组学就是基因组学.
  • 个性化医疗是个性化的医疗.

背景情况:

  • 综合分子分析 (CMP) 和分子匹配疗法 (MMT) 在先进的固体瘤中的作用仍然不确定.
  • 本研究调查了CMP和MMT在俄罗斯的现实应用和影响.

研究的目的:

  • 评估与CMP和MMT相关的临床实用性和结果,在俄罗斯一组患有晚期固体瘤的患者中.
  • 评估执行率和不遵守MMT的原因.

主要方法:

  • 一项回顾性多中心研究分析了448名患有高级非血液性恶性瘤的患者的CMP数据.
  • 基因组变化 (GA) 使用ESMO分子标 (ESCAT) 临床可操作性尺度进行分类.
  • 在接受MMT和不接受MMT的患者之间比较了结局.

主要成果:

  • 分子匹配疗法 (MMT) 建议用于56.9%的患者,但仅在23.2%的患者中实施.
  • 与非MMT组相比,MMT组的客观应答率 (61.3%与37.1%) 显著提高,无进展生存率有所改善.
  • 使用MMT观察到显著的整体存活率增长,特别是在ESCAT III-V基因组改变的患者中,那些先前治疗有限的患者,良好表现状态和分子瘤委员会讨论.

结论:

  • 在CMP之后的MMT为高级固体瘤的选定患者提供了显著的临床益处,包括ESCAT III-V基因组改变的患者.
  • 这些发现支持将CMP和MMT整合到常规瘤实践中,以进行个性化癌症治疗.