相关实验视频

Updated: Sep 19, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

局部胰岛素治疗对糖尿病足的影响:系统性审查和元分析

Shibei Hu¹, Yan Gong², Huiqi Zhang¹

¹Dazhou Dachuan District People's Hospital (Dazhou Third People's Hospital), China.

Journal of tissue viability

|June 18, 2025

概括

局部胰岛素治疗显著加速愈合,并减少糖尿病足的炎症. 然而,它对血糖水平的影响需要进一步研究.

科学领域:

伤口愈合研究研究研究
糖尿病学糖尿病学
药理学药理学是指药理学的学科.

背景情况:

糖尿病足 (DFU) 是糖尿病的一个主要并发症,导致严重的发病率和医疗费用.
目前用于DFU的治疗方法通常有效性有限,需要新的治疗方法.

研究的目的:

系统地审查和分析局部胰岛素治疗在治疗糖尿病足部的疗效.
为DFU管理中局部胰岛素的临床应用提供基于证据的指导.

主要方法:

一项量化系统性审查和对评估DFU局部胰岛素治疗的研究的元分析.
包括12项研究,共731名患者,来源于9个主要数据库.
研究注册和遵守已建立的协议 (PROSPERO CRD42024581466).研究注册和遵守已建立的协议.

主要成果:

与传统治疗相比,局部胰岛素治疗显著减少了伤口愈合时间和部面积 (P < 0.001).
它导致炎症标志物 (IL-1,IL-6,TNF-α) 和高级糖化终产物 (P < 0.001) 的减少.
在颗粒组织再生,微血管密度,VEGF表达和β-catenin水平 (P < 0.001) 中观察到改善,但对空腹血葡萄糖 (P > 0.05) 没有显著影响.

结论:

局部胰岛素治疗在促进伤口愈合和调节糖尿病足患者的炎症方面表现出显著的疗效.
局部胰岛素对全身血糖控制的影响仍然没有确定性.
建议进行高质量的随机对照试验,以进一步验证这些发现,并澄清其在DFU治疗中的作用.

关键词:

糖尿病足患者的糖尿病足.基于证据的护理.足部足部足部足部进行元分析分析.局部胰岛素治疗局部胰岛素治疗

更多相关视频

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

相关概念视频

Diabetes: Management and Pharmacotherapy

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...

Insulin: Dosing Regimen and Adverse Effects

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Oral Hypoglycemic Agents: Biguanides and Glitazones

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...