PFAS与注意力缺陷/多动障碍或自闭症谱系障碍之间的关系:流行病学和实验证据
Keyue Wu1, Aoxue Tang1, Xing Zhang2
1School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 561113, China; Department of Occupational and Environmental Health, School of Public Health, Guizhou Medical University, Guiyang, Guizhou 561113, China.
Ecotoxicology and environmental safety
|June 18, 2025
概括
暴露于和多基物质 (PFAS) 可能与儿童的注意力缺陷多动症 (ADHD) 和自闭症谱系障碍 (ASD) 有关. 研究表明,PFAS可能会损害发育中的大脑,影响神经发育.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是无处不在的环境污染物,在食品,水和人体组织中检测到.
- 由于潜在的神经毒性影响,PFAS暴露越来越令人担忧,特别是在脆弱人群 (如胎儿和婴儿) 中.
- 发育中的大脑非常容易受到环境的侮辱,这是由于不成熟的保护屏障和免疫系统.
研究的目的:
- 审查和综合目前的流行病学和实验证据,关于PFAS暴露对神经发育的影响.
- 专注于PFAS暴露与注意力缺陷多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD) 的发展之间的潜在关联.
- 确定挑战和未来的研究方向,以了解PFAS和神经发育障碍之间的因果关系.
主要方法:
- 现有流行病学研究的叙述性审查 (横截面和前性队列).
- 对实验 (体内和体外) 研究PFAS神经毒性机制的分析.
- 综合有关PFAS对神经递质调节,氧化应激,神经炎症和肠道微生物群的影响数据.
主要成果:
- 流行病学数据表明,PFAS暴露与ADHD和ASD风险增加之间存在潜在的关联.
- 实验研究表明,暴露于PFAS可以破坏神经递质系统,诱导氧化应激和神经炎症,并改变肠道微生物群的组成.
- 这些干扰与ADHD和ASD模型中观察到的病理特征保持一致.
结论:
- 目前的证据表明,PFAS暴露与ADHD和ASD等神经发育障碍之间存在可信的联系.
- 进一步的研究,包括分子流行病学和精细的动物暴露模型,对于确定因果关系至关重要.
- 了解PFAS神经毒性的精确机制对于公共卫生干预至关重要.
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