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从HPV阳性精子中获得的胚胎的形态动力学是否发生变化? 一个回顾性队列研究
Giorgio Maria Baldini1, Daniele Ferri2, Dario Lot2
1Obstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
Gynecologic and obstetric investigation
|June 18, 2025
概括
男性人类乳头瘤病毒 (HPV) 感染不会对精子参数,胚胎发育或辅助生殖技术 (ART) 成功率产生负面影响. 根据这些发现,接受ART的男性可能不需要进行常规HPV查.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 胚胎学 胚胎学
背景情况:
- 男人乳头瘤病毒 (HPV) 是一种常见的性传播感染.
- 男性HPV对辅助生殖技术 (ART) 结果的影响尚未完全理解.
- 精子质量和胚胎发育对于成功的ART至关重要.
研究的目的:
- 为了研究男性HPV感染对精子参数的影响.
- 为了评估男性HPV在ART期间对胚胎形态动力学的影响.
- 评估男性HPV对ART临床怀孕和流产率的影响.
主要方法:
- 对3360个ART周期 (2019-2023) 的回顾性队列研究.
- 57名HPV阳性男性与57名匹配的HPV阴性对照进行了细胞内质精子注射 (ICSI).
- 分析精子参数,胚胎形态动力学和ART结果;试管婴儿人员对HPV状况失明.
主要成果:
- 在HPV阳性和HPV阴性组之间的精子参数中没有观察到统计学上显著的差异.
- 胚胎形态动力学和ART结果,包括怀孕和流产率,在两组之间是可比的.
- 在这两组中,胚胎细胞转移时间和高质量的胚胎的转移是相似的.
结论:
- 男性HPV感染似乎不会对胚胎发育或ART成功率产生不利影响.
- 目前的研究结果表明,在接受ART的男性伴侣中,例行HPV查可能在临床上不必要.
- 需要进一步研究,采用更大的样本大小和延长后续调查.
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