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Updated: Sep 19, 2025

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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在血液形成过程中,双对应染色体指导谱系的规范

Masaki Yagi1, Gracia Bonilla2, Michael S Hoetker1

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|June 18, 2025
PubMed
概括

基因组甲基化,特别是H3K4甲基化,对于血液细胞的发育至关重要. 减少H3K4甲基化导致严重的造血失败,突出显示了它在原始细胞成熟中的重要作用.

关键词:
H3K27甲基化H3K27M 其他H3K4甲基化H3K4M 其他双价基因差异化血液形成造血干细胞和原生细胞基斯甲基化lysine-to-methionine 的突变

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Commitment is the  process whereby stem cells:
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