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Updated: Sep 19, 2025

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高吞吐量冷-EM 提供了对 lysosomal 离子通道 TRPML1 的调节器的结构理解

Judith Reeks1, Pravin Mahajan1, Mellissa Clark1

  • 1Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK.

Structure (London, England : 1993)
|June 18, 2025
PubMed
概括

低温电子显微镜 (cryo-EM) 使用十个调制器使TRPML1通道的高分辨率结构成为可能. 这为改善药物设计提供了关键的 ligand 诱导通道封闭的见解.

关键词:
在TRPML1中使用.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.lysosomal 离子通道 离子通道 离子通道结构的确定 结构的确定基于结构的药物设计.

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