相关实验视频

Updated: Sep 19, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

固态选和干粉吸入器开发的ziyuglycoside II盐提高生物可用性

Hanwen Zhang¹, Siwen Wang², Sara Slimani²

¹College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.

International journal of pharmaceutics

|June 18, 2025

概括

齐尤格利科西德II (ZYG II) 由于溶解性差,其生物利用性较低. 开发ZYG II盐 (ZYG-II-Na) 干粉吸入器显著改善了其吸收和生物可用性.

科学领域:

药理学药理学是指药理学的学科.
材料科学材料科学材料科学
药物运输药物运输药物运输

背景情况:

来自Sanguisorba officinalis L.的沙波宁Ziyuglycoside II (ZYG II) 具有有限的药理作用,原因是其口服生物利用率低 (<5%),由于溶解性低,透性低,以及广泛的第一通代谢.
提高ZYG II的生物可用性对于其治疗应用至关重要.

研究的目的:

为了提高zyuglycoside II (ZYG II) 的可溶性和口服生物利用性.
开发和描述ZYG II盐 (ZYG-II-Na) 的固体形式,并制定干粉吸入器 (DPI) 进行增强的肺部输送.

主要方法:

使用结构分析,稳定性评估和粉末评估,对ZYG-II-Na固体形式 (晶体和无形) 的系统选和表征.
在小鼠体内溶解性研究和体内药理动力学评估.
ZYG-II-Na DPI的配方和空气动力学评估.

主要成果:

确定了三种晶体 (I,II,III) 和两种无形 (I,II) 的ZYG-II-Na形式,其中无形I和II表现出增强的可溶性稳定性.
与其他形式相比,水晶III表现出优越的湿度稳定性.
与口服 (3.53%) 相比,ZYG-II-Na DPI在老鼠中使用导致生物可用性显著增加 (水晶I的8.54%,无形II的16.8%).

结论:

固体形式优化和DPI配方有效地克服了ZYG II的生物可用性限制.
通过DPI输送的无形ZYG-II-Na提供了一种有前途的策略,可以提高这种沙素的治疗效果.

关键词:

生物可用性生物可用性干粉吸入器干粉吸入器萨波尼尼的使用方法固态选固态选固态选齐尤格利科西德II 盐

更多相关视频

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Intratracheal Administration of Dry Powder Formulation in Mice

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

相关概念视频

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...