使用溶解微针集成与新的插入和移除指示器,通过皮肤输送恩福维
Huanhuan Li1, Lalitkumar Vora1, Yaocun Li1
1School of Pharmacy, Queen's University Belfast, BT9 7BL, United Kingdom.
概括
溶解微针阵列补丁 (DMAPs) 提供了一种无痛的替代方法,用于输送恩富维尔提德,克服注射部位的反应. 新型PLA-化DMAP提供视觉反,以优化药物输送和患者的坚持.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 恩福维尔提德是一种关键的HIV融合抑制剂,在皮下注射时面临挑战,导致频繁的注射部位反应 (ISR).
- 由于不适和副作用,目前的施用方法限制了患者的坚持和治疗结果.
研究的目的:
- 开发和评估可溶解微针阵列补丁 (DMAPs) 以无痛和高效的恩富维尔提德输送.
- 设计具有集成色度指标的DMAP,用于实时监测药物输送和贴片去除.
主要方法:
- 使用聚乙烯 (PVP) 和聚乳酸 (PLA) -复合材料制造双层DMAP.
- 结合了新型的PLA-基板与水晶紫色染料,用于色度溶解指示.
- 在体内评估DMAP的性能,包括药物释放动力学,生物相容性和Sprague Dawley大鼠的安全性.
主要成果:
- PLA-酸DMAP表现出快速的颜色变化 (在3分钟内从黄色变成绿色,然后在2小时内变成紫色),表明成功插入和溶解.
- 与基于PVP的DMAP相比,Enfuvirtide与PLA-基DMAP实现了更高的Cmax (1864±480 ng/mL在0.5小时),而不是基于PVP的DMAP (973±200 ng/mL在1小时).
- 这两种DMAP配方在体内都具有生物相容性和安全性,PLA-DMAP适合快速释放,PVP-based DMAP适合持续释放.
结论:
- DMAPs代表了一个有前途的,患者友好的替代品,以皮下注射恩福维,潜在地减少ISRs和改善坚持.
- 综合色度指标为监测药物输送和优化剂量方案提供了一种新的解决方案.
- 这项技术有助于个性化的恩富维尔提德 (enfuvirtide) 给药,提高了可靠性和患者接受度,以便广泛采用.
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