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深度硬膜切除术对视网膜血管密度和视野功能的短期影响在初级开角玻璃眼中

Nazli Taheri¹, Ali Mostafaie¹, Mohamad Reza Niyousha¹

¹Department of Ophthalmology, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, , Iran.

Photodiagnosis and photodynamic therapy

|June 18, 2025

概括

在初级开角青光眼患者中,米托米辛C增强的非透性深度硬膜切除术显著降低了眼内压力,改善了视野平均偏差. 视网膜微血管学没有显示短期变化,但观察到血管密度和视野功能之间的相关性.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
手术干预手术干预

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
有效的管理策略对于减缓疾病进展和保持视力至关重要.
非穿透性深度硬膜切除术 (NPDS) 是一种手术选择,用于降低眼内压力 (IOP).

研究的目的:

评估米托米辛C增强NPDS对POAG患者视网膜微血管和视野功能的直接影响.
在手术后评估眼内压力 (IOP),视野平均偏差 (MD) 和模式标准偏差 (PSD) 的变化.
为了研究视网膜血管密度 (VD) 和视野参数在NPDS后的关系.

主要方法:

一项前性单臂干预研究,涉及22名POAG患者的22只眼睛.
在眼睛上进行的NPDS手术,眼睛的玻璃眼进展或不受控制的IOP.
评估包括IOP,Humphrey视野 (HVF) 30-2,RNFL和OCTA衍生的视神经头部 (ONH) 和斑点的视力损伤,在手术前和一个月后测量.

主要成果:

手术后一个月,内血压从23.5mmHg显著降低到8mmHg (p<0.001).
视野MD从-15.44dB显著改善到-13.06dB (p=0.038),而PSD没有显著变化.
没有检测到周围毛囊或黄斑性静脉疾病的显著变化,但术后的MD与ONH和黄斑性静脉疾病正相关.

结论:

与米托米辛C增强的NPDS在显著降低POAG患者的IOP方面是有效的.
该程序没有证明视网膜微血管结构的短期显著变化.
视网膜VD和视野MD之间的相关性表明,眼中视野缺陷的潜在血管机制.

关键词:

深度脊髓瘤切除术 (deep sclerectomy) 是一种深度脊髓瘤切除术.眼光障碍症是什么眼光障碍症是什么这是NPDS的NPDS.没有穿透的深度脊髓切除术.八国合作组织 (OCTA)波阿格 (POAG) 是一个船舶密度船舶密度船舶密度

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