有机酸阻燃剂对海洋微藻Chaetoceros muelleri的毒性影响:从生理学和转录组分析的见解
Yu-Xin Wu1, Su-Chun Wang2, Fei-Fei Liu3
1Institute of Marine Science and Technology, Shandong University, Qingdao, Shandong, 266237, China.
Environmental pollution (Barking, Essex : 1987)
|June 18, 2025
概括
有机酸盐阻燃剂 (OPFRs) 通过破坏细胞和抑制生长来伤害海洋微藻. 这些化学物质破坏光合作用,并引发氧化应激,影响水生生态系统.
科学领域:
- 环境科学 环境科学
- 海洋生物学 海洋生物学
- 毒理学 毒理学 毒理学
背景情况:
- 有机酸盐阻燃剂 (OPFR) 被广泛使用,导致环境污染.
- 它们对关键的初级生产者海洋微藻的影响仍未得到充分研究.
研究的目的:
- 评估三种OPFR (EHDPP,TCP,TPhP) 对海洋微藻Chaetoceros muelleri的毒性.
- 通过转录基因分析阐明了OPFR毒性背后的分子机制.
主要方法:
- 对Chaetoceros muelleri暴露于不同度的EHDPP,TCP和TPhP.
- 增长抑制,细胞形态和核糖体完整性的评估.
- 转录组分析以确定受影响的基因表达途径.
主要成果:
- 在C. muelleri.中,OPFRs引起显著的细胞变形和生长抑制.
- 核糖体结构和功能受损,影响光合作用蛋白质合成.
- 观察到叶绿素合成减少,光能转化受损,电子转移受阻.
- 增加的活性氧物种 (ROS) 和脂质过氧化表明氧化应激.
结论:
- OPFR对海洋微藻构成严重的有毒威胁.
- 机制包括破坏蛋白质合成,光合作用和诱导氧化应激.
- 这些发现凸显了水生环境中OPFRs的潜在生态风险.
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