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职业接触无形二氧化纳米粒子会改变肺功能和代谢特征

Xuemin Shi¹, Chen Liang², LinLin Wang³

¹Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; School of Public Health, Baotou Medical College, Inner Mongolia University of Science & Technology, Baotou 014040, PR China; Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, PR China.

Toxicology letters

|June 18, 2025

概括

对无形纳米粒子 (SiNPs) 的职业暴露显著损害了肺功能,并改变了工人的血清代谢物. 这些发现突出了与SiNPs相关的潜在健康风险,并表明与环境污染物的相互作用.

科学领域:

纳米材料的毒理学
职业健康职业健康职业健康职业健康
环境健康环境健康

背景情况:

无形纳米粒子 (SiNPs) 在工业应用中很普遍.
虽然动物研究表明SiNPs会导致肺损伤,但人类流行病学数据很少.
了解职业SiNP暴露对人类健康的影响至关重要.

研究的目的:

研究职业SiNP暴露对人类肺功能和血清代谢物的影响.
探索肺功能变化和血清代谢物概况之间的相关性.
为了确定受SiNP暴露影响的特定代谢途径.

主要方法:

基于人口的研究,将15名暴露于SiNP的工人与45名健康对照进行比较.
使用螺旋计 (FVC,FEV1,FEF25-75%) 评估肺功能.
非向的高分辨率代谢组分分析血清代谢物和斯皮尔曼相关性,以分析结果关联.

主要成果:

胸部X射线显示暴露工人的肺部标记异常.
暴露的工人表现出明显较低的肺功能参数 (FVC,FEV1,FEF25-75%).
确定了15种改变的血清代谢物,主要是脂质和氨基酸,SiNP暴露破坏了三聚,氨酸和脂代谢.

结论:

职业SiNP暴露与人类的肺功能受损有关.
暴露于SiNP会改变血清代谢物概况,可能影响代谢途径.
SiNP可能会影响其他环境污染物的吸收和代谢,如TEMPO和PFOS.

关键词:

代谢学代谢学代谢学职业暴露职业暴露肺功能肺功能肺功能纳米颗粒是一种.

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