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肠道微生物组与新生儿的胰岛结构有关

Michelle Graf¹, Nicolas Murgueitio², Margaret A Sheridan²

¹School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Virginia Commonwealth University, School of Nursing, Richmond, VA, USA.

Physiology & behavior

|June 18, 2025

概括

早期婴儿肠道微生物组的组成与大脑结构的发展有关. 特定的细菌,如Veillonella,与大脑区域体积相关,这表明新生儿的肠-大脑轴正在发展.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
发展生物学发展生物学

背景情况:

婴儿的大脑和肠道微生物组在生命早期经历了快速发展.
新出现的证据表明,肠道微生物组影响神经发育,特别是在处理影响,互感觉和感官信息的区域.

研究的目的:

为了研究2周大的婴儿肠道微生物组和大脑结构之间的联系.
确定与新生儿大脑发育相关的特定微生物特征.

主要方法:

磁共振成像 (MRI) 用于评估大脑体积.
便样本的全基因组测序描述了肠道微生物组的组成.

主要成果:

在肠道微生物组特征和大脑区域的体积之间发现了显著的关系,这些区域参与了情感,感官和整体感知处理.
在insula体积和Veillonella丰富度之间观察到负相关性.
阿尔法多样性和功能途径也与胰岛结构相关; 肠道细菌的丰富性与 thalamus 体积有负相关.

结论:

这些发现支持一个正在发展的肠-大脑轴,证明了肠道微生物群和大脑结构之间的早期联系在2周大时.
在新生儿时期,胰岛似乎对肠道微生物群的影响特别敏感.
需要进一步的研究来探索这些早期肠-大脑相互作用对神经发育和行为的机制和长期影响.

关键词:

阿米格达拉的一个桃体.岛屿岛屿 (英语:Insula) 是一个岛屿.微生物组是一个微生物组.新生儿新生儿新生儿泰拉姆斯 (thalamus) 是一个神经元.

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