通过基于废水的流行病学监测社区使用二胺
Maarten Quireyns1, Tim Boogaerts1, Natan Van Wichelen1
1Toxicological Centre, University of Antwerp, Wilrijk, Belgium.
Drug testing and analysis
|June 18, 2025
概括
对二类药物 (BZD) 的废水分析揭示了消费模式,但需要仔细解释. 区分直接和下游生物标志物对于准确监测这些广泛使用的药品至关重要.
科学领域:
- 环境化学环境化学
- 法医毒理学 法医毒理学
- 药品分析 药品分析
背景情况:
- 二类药物 (BZDs) 和相关的z药物被广泛处方,但存在依赖和有效性有限的风险.
- 基于废水的流行病学 (WBE) 为整个人口提供了对毒品消费的洞察力.
- BZDs的代谢途径重叠可能会使WBE中的消费解释复杂化.
研究的目的:
- 开发和验证废水中26种BZD生物标志物的分析方法.
- 将该方法应用于四个欧洲国家废水样本,其中BZD市场不同.
- 将BZD生物标志物分为直接类型和下游类型,以改善数据解释.
主要方法:
- 固相提取 (SPE) 和液态染色学-并联质谱学 (LC-MS/MS) 用于生物标志物分析.
- 在比利时,拉脱维亚,立陶宛和罗马尼亚的18个地点收集了废水流入样本.
- 开发了BZD生物标志物的结构化分类,以区分直接和下游代谢物.
主要成果:
- 经过验证的方法成功量化了废水中的26种BZD生物标志物.
- 观察到BZD消费的空间变化,比利时使用佐洛皮的比例较高,里加使用佐皮克隆.
- 下游生物标志物显示较高的负载,但由于共享的代谢途径,需要仔细解释.
结论:
- 准确地解释废水中的BZD消耗需要区分直接和下游生物标志物.
- 这种方法对于可靠的监测和关于药物使用的知情决策至关重要.
- 该研究强调了药物监测中精细的WBE方法的挑战和必要性.
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