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由Ganoderma lucidum相关的内性Trichoderma sp.产生的天然循环. 在GLQ02中,我们使用了GLQ02

Xin-Huan Qiu¹, Qing Guo², Dong-Yu Wang¹

¹Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

|June 18, 2025

概括

三种来自真菌Trichoderma sp.的新型环. 被孤立和研究. 化合物1通过降低关键炎症标志物的调节,显示出潜在的抗炎活性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.

背景情况:

内生真菌,如Trichoderma物种,是生物活性天然产品的丰富来源.
光 (Ganoderma lucidum) 以其药用特性而闻名,其相关的内可能产生新型化合物.
环酸代表了各种各样的自然产品类别,具有广泛的生物活性.

研究的目的:

从内生菌真菌Trichoderma sp.中分离和表征新型环. 在GLQ02.02中,我们使用了GLQ02.
评估已分离的环酸的抗炎和抗微生物潜力.
为了确定新型环酸天然产品的结构和绝对配置.

主要方法:

使用染色学技术分离环.
通过广泛的光谱分析 (NMR,MS) 和X射线晶体学来阐明结构.
使用马菲方法和生物遗传分析确定绝对配置.
在体外测定抗炎性 (细胞因子mRNA表达) 和抗菌活性.

主要成果:

分离了8种环 (1-8),其中包括3种以前未被描述的化合物 (1, 4, 7).
所有化合物的结构和绝对配置得到了确认.
化合物1通过降低IL-6,IL-1β和MCP-1的mRNA表达来证明抗炎作用的潜力.
没有一个环类 (1-8) 在10 mg/mL时表现出抗菌活性.

结论:

三皮虫 sp. 在光的内生植物GLQ02可以产生新型环酸.
化合物1表现出有希望的抗炎性质,需要进一步调查.
在这项研究中,分离的环酸没有显示出显著的抗菌活性.

关键词:

(Ganoderma lucidum) 相关的内性真菌菌生物活动生物活动这是天然的环酸.三皮虫 sp. 在在GLQ02中,我们使用了GLQ02

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