在中年运动员中,运动诱导的心脏热素升高和隐形冠状动脉样硬化之间的关系
Sylvan L J E Janssen1, Wouter M van Everdingen2, Wouter B J Saalmink1
1Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Journal of the American College of Cardiology
|June 18, 2025
概括
运动员运动后心脏中高水平的热素 (cTn) 与冠状动脉样硬化无关. 这表明运动诱导的cTn的变化不是由于潜在的心脏病.
科学领域:
- 心脏病学 心脏病学
- 运动医学 运动医学
- 生物标志物 生物标志物
背景情况:
- 运动通常会提高心脏中热素 (cTn) 水平.
- 在运动后的cTn反应中存在显著的个体变异.
研究的目的:
- 为了比较娱乐运动员的冠状动脉样硬化患病率和严重程度,运动后cTn度高低.
- 研究运动诱导的cTn升高与潜在的冠状动脉疾病之间的关系.
主要方法:
- 在 1,011 名运动员中,在运动前和运动后评估了高灵敏性心脏托洛T (hs-cTnT) 和hs-cTnI.
- 对匹配的高 (n=68) 和低 (n=34) cTn反应者进行心脏CT扫描,以评估冠状动脉样硬化 (CAD-RADS,分数).
- 利用CT衍生分流储备 (CT-FFR) 来评估冠状动脉狭窄症的功能意义.
主要成果:
- 在高和低cTn响应者之间没有发现冠状动脉样硬化患病率或严重程度的显著差异.
- CT-FFR分析显示,两组之间狭窄症的血液动力学相关性没有差异.
- 在hs-cTnT/hs-cTnI水平和CAD-RADS分类之间观察到弱相关性.
结论:
- 在休运动员中,运动后cTn度与冠状动脉样硬化的存在或程度无关.
- 运动引起的cTn升高的个体间差异可能不能由隐性冠状动脉疾病解释.
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