深度学习用于心脏过载估计 - 从心脏声音和心电图中预测B型尿素 (BNP) 水平
Shimpei Ogawa1, Masanobu Ishii2,3, Shumpei Saito1
1AMI Inc.
概括
一种新的深度学习模型使用心脏声音和心电图估计B型性尿素 (BNP) 水平,为心力衰竭 (HF) 查提供了一种非侵入性工具. 这种方法对快速,客观的护理点HF检测有希望.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 人工智能在医学中的应用
背景情况:
- B型性 (BNP) 和N终端亲BNP (NT-pro-BNP) 是心力衰竭 (HF) 管理的关键生物标志物.
- 对于HF的传统听觉缺乏客观的评估.
- 声心电图仪器可以快速记录心脏声音和心电图.
研究的目的:
- 开发一种深度学习模型,通过非侵入性心脏声音和心电图信号来估计血BNP水平.
- 用外部数据集验证模型的性能.
- 评估这种非侵入性方法对HF查的临床可行性.
主要方法:
- 开发了一种深度学习模型,使用8秒钟的心声和心电图记录来估计BNP水平.
- 该模型在140名患者的外部验证数据集上进行了评估.
- 对具有特定体重指数范围的患者进行了亚组分析.
主要成果:
- 估计的BNP (eBNP) 模型实现了0.895的接收器运行特征曲线 (AUROC) 下的面积,用于预测BNP水平≥100 pg/mL.
- 敏感度和特异性分别为84.3%和82.9%.
- 在一个子组 (BMI 18.5-25),该模型显示了增强的预测能力,AUROC为0.959,灵敏度为92.5%,特异性为84.8%.
结论:
- 该eBNP模型显示了非侵入性和快速心力衰竭查的巨大潜力.
- 它的客观和简单的性质使它适合于点的护理测试.
- 该模型在不同人群中的稳定性,在独立数据集上得到验证,支持其用于早期HF诊断和监测.
相关概念视频
01:29Heart Failure II: Pathophysiology
59
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
59
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
223
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
223
01:30Pulse rhythm
937
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
937
01:30Cardiomyopathy II: Dilated Cardiomyopathy
30
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
30
01:29Electrocardiogram
3.3K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
3.3K