基于早晨血液中的皮质醇水平,在治疗时基于osilodrostat的库辛综合征的安全管理
Takuyuki Katabami1, Ren Matsuba1, Tomoyuki Nagasaka1
1Department of Metabolism and Endocrinology, St. Marianna University Yokohama Seibu Hospital, Yokohama 241-0811, Japan.
Endocrine journal
|June 18, 2025
概括
同时测量血清皮质醇和24小时尿液自由皮质醇 (UFC),可以帮助调整库辛综合征 (CS) 患者的静止止剂剂量. 这种方法有助于迅速和安全的治疗调整.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 临床化学 临床化学
背景情况:
- 奥西洛德罗斯塔特剂量调整依赖于24小时尿液自由皮质醇 (UFC),但结果需要1周左右.
- 血清皮质醇提供更快的结果,可能使剂量更快地调整.
- 同时进行血清皮质醇和UFC测定对静止剂管理的实用性尚未得到充分证实.
研究的目的:
- 为了评估同时进行血清皮质醇和UFC测定在接受osilodrostat治疗的库辛综合征 (CS) 患者中的有用性.
主要方法:
- 追溯的横截面研究分析了来自6名CS患者的71个配对样本在osilodrostat.
- 在同一天收集了UFC的24小时尿液和血清上午血清皮质醇.
- 使用商用免疫测试套件进行激素测量.
主要成果:
- 在早晨血清皮质醇和UFC水平之间发现了显著的正相关性.
- 血清皮质醇切断值为21.5μg/dL预测高UFC (>正常的3×上限).
- 血清皮质醇对低UFC具有较低的积极预测值;<5.0μg/dL的水平识别了低皮质醇症,即使具有不一致的UFC.
结论:
- 同时测量早晨血清皮质醇和UFC促进了OS患者在CS患者的安全性.
- 血清皮质醇可以帮助快速评估,但UFC对于全面监测至关重要.
- 这种综合方法支持及时和安全的静脉缩剂剂量调整.
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