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Updated: Sep 19, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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阻断XIAP:CASP7-p19通过一种新型可逆小分子选择性诱导CASP3/DR恶性瘤的亡

Shih-Hsun Chen1, Szu-Ying Wu2, Yun-Xun Chang2

  • 1Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan. shichen@ntu.edu.tw.

Cell death & disease
|June 18, 2025
PubMed
概括

研究人员确定了一种新的可逆抑制剂643943,向XIAP:CASP7相互作用. 这种化合物选择性地杀死具有低卡斯巴-3水平的耐药癌细胞,为特定恶性瘤提供了一种新的治疗策略.

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