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Updated: Sep 19, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Published on: June 27, 2020

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欧核细胞转录因子的co-TF依赖的分歧涉及多个内在无序的区域

Lindsey F Snyder1, Emily M O'Brien2, Jia Zhao2,3

  • 1Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA.

Nature communications
|June 18, 2025
PubMed
概括

转录因子 (TFs) 控制基因调节. 转基因固有无序区域 (IDR) 的分歧影响了它们的相互依赖和演变,影响了基因激活潜力和自身抑制.

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General Transcription Factors01:30

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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