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Updated: Sep 19, 2025

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在乳腺癌中,PTEN无化加剧了CDK4/6抑制剂的耐药性

Fan Liu1,2, Weixiao Liu1,2, Yawen Tan3

  • 1Department of Cell Biology, Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.

Oncogene
|June 18, 2025
PubMed
概括

准PTEN缩,使瘤抑制剂失活并驱动乳腺癌,可以克服对Palbociclib的耐药性. 乙可胺抑制PTEN脱,恢复瘤抑制并提高治疗疗效.

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