在上皮细胞和B细胞中,R9AP是EBV感染的常见受体
Yan Li1,2, Hua Zhang3, Cong Sun1
1State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Nature
|June 18, 2025
概括
R9AP被确定为爱斯坦巴尔病毒 (EBV) 进入上皮细胞和B细胞的常见受体. 这一发现为新的EBV预防和疫苗策略提供了潜在的目标.
科学领域:
- 病毒学
- 免疫学
- 细胞生物学
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 感染了90%以上的人类,导致各种疾病.
- 对于上皮和B细胞感染,EBV使用不同的宿主受体.
- 这两种细胞类型的EBV输入的共同受体以前是未知的.
研究的目的:
- 鉴定埃普斯坦-巴尔病毒 (EBV) 进入上皮细胞和B细胞的常见受体.
- 阐明EBV受体相互作用和病毒进入的机制.
- 探索R9AP作为EBV治疗的潜在目标.
主要方法:
- 进行R9AP基因沉默和淘汰实验.
- 结合和吸收EBV测试.
- 共同免疫沉和西式涂抹以研究蛋白质相互作用.
- 使用抗体进行中和测定.
主要成果:
- R9AP被确定为EBV进入上皮细胞和B细胞的关键受体.
- R9AP直接与EBV的gH/gL复合体结合,从而启动膜融合.
- 抑制R9AP或其与gH/ gL受阻的EBV感染的相互作用.
- 在病毒进入过程中,R9AP与特定的EBV糖蛋白复合物合作.
结论:
- R9AP是EBV进入上皮和B细胞的常见受体.
- 在开发EBV预防和疫苗策略方面,R9AP是一个有前途的目标.
- 了解R9AP的作用可以提高EBV病变和控制的知识.
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.4K
Rab Proteins
4.1K
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
4.1K
Diversity of Antigen Receptors
818
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
818
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K


