通过益生菌减轻结肠直肠癌:目前的证据和未来的方向
Priyanka Chaturvedi1, Rimjhim Pathak2, Ranu Dayal1
1Department of Botany/Agriculture Sciences, Dayalbagh Educational Institute, Dayalbagh, Agra, 282005, Uttar Pradesh, India.
Current microbiology
|June 18, 2025
概括
益生菌,包括Lactobacillus和Bifidobacterium,在通过各种机制预防结肠直肠癌 (CRC) 方面表现有前途. 需要进一步的人体试验来确认它们在癌症化学预防中的有效性.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 癌症研究 癌症研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症相关死亡的主要原因,发展中国家的发病率正在上升.
- 益生菌正在研究其在CRC预防中的潜在作用,特别是来自Lactobacillus和Bifidobacterium属的物种.
研究的目的:
- 审查益生菌可以预防结直肠癌 (CRC) 的拟议机制.
- 突出特定益生菌菌株的重要性以及进一步临床验证的必要性.
主要方法:
- 对抗CRC的益生菌机制的体外和动物研究的审查.
- 分析拟议的途径,包括直接的粘膜相互作用,病原体对抗,致癌物结合和免疫调节.
主要成果:
- 益生菌可以通过粘附于肠道内膜来预防CRC,排除病原体,结合致癌物,并抑制β-glucuronidase等有害酶.
- 益生菌可以调节抗瘤免疫反应,并影响二次胆酸产生和叶酸代谢.
- 特定的微生物菌株至关重要,益生菌活力可能并不总是必要的抗癌效应.
结论:
- 益生菌为结直肠癌 (CRC) 的化学预防提供了多种潜在机制.
- 进一步的体内研究,特别是人类临床试验,对于验证益生菌,益生菌和共生菌在CRC预防中的作用至关重要.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
430
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
430
Chronic Bowel Disorders: Introduction
543
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
543
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Drugs for Treatment of Constipation-Predominant IBS
353
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
353
Inflammatory Bowel Disease V: Surgical Management
225
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
225
Inflammatory Bowel Disease IV: Pharmacological Management
204
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
204


