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在男性中使用兴奋剂,艾滋病毒和血代谢物
Emily M Cherenack1, Michaela E Larson2, Kevin Murray3
1Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
概括
代谢学揭示了性少数群体男性 (SMM) 与艾滋病毒和兴奋剂使用同时发生的显著的血代谢物变化. 这些发现突出了神经免疫和心脏代谢健康干预的潜在生物标.
科学领域:
- 生物化学 生化学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 代谢学提供了一种强大的方法来识别生物点,以减轻对健康的负面影响.
- 性少数群体男性 (SMM) 被艾滋病毒和兴奋剂使用不成比例地影响,影响神经免疫和心脏代谢健康.
- 有限的数据存在于SMM的血代谢组变化与独立或同时发生的HIV和兴奋剂使用.
研究的目的:
- 在四个组中对SMM的血代谢组进行表征:没有HIV/没有使用兴奋剂,HIV阳性/没有使用兴奋剂,没有HIV/使用兴奋剂,以及HIV阳性/使用兴奋剂.
- 为了确定与独立和同时发生的艾滋病毒和兴奋剂使用相关的特定代谢物.
- 探索已识别的代谢物在免疫失调,成,能量代谢和心血管疾病中的潜在作用.
主要方法:
- 在佛罗里达州迈阿密 (2020-2022) 收集了61名社区招募的SMM的血样本.
- 评估生物确认的艾滋病毒状况和兴奋剂的使用.
- 利用质谱分析390种血代谢物,并采用双变量分析和多变量回归与错误发现率校正.
主要成果:
- 六种代谢物 (胆,三,两种溶解脂胆,一种三糖化物,一种二糖化物) 在两组之间显示出显著的差异 (p < 0.05).
- 在FDR校正后,艾滋病毒阳性/使用兴奋剂的组与没有艾滋病毒/没有使用兴奋剂的组相比,呈现较低的酸.
- 与其他相关组相比,HIV阳性/使用兴奋剂的组显示出较高的lysophosphatidylcholine a C18: 1和三糖{20:3_34: 0}.
结论:
- 在SMM中同时出现的兴奋剂使用和艾滋病毒感染与特定的血代谢物的显著干扰有关.
- 代谢物,如酸和lysophosphatidylcholines可能在免疫失调,成,能源使用和心血管疾病中发挥作用.
- 需要进一步的研究,包括干预试验,以阐明兴奋剂使用与观察到的代谢变化之间的因果关系.
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