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Chen Lin^1,2,3, Robijn Bruinsma⁴

¹University of California, Los Angeles, Department of Chemistry and Biochemistry, California 90095, USA.

Physical review. E

|June 19, 2025

概括

在狭窄的空间中,活性液体-液体相隔离 (LLPS) 可以打破细节平衡. 引入滴滴位置作为第二个坐标显示活跃噪声抑制系统动态不对称.

科学领域:

细胞生物学细胞生物学
生物物理学的生物物理.
统计力学就是统计力学.

背景情况:

液-液相分离 (LLPS) 在细胞过程中至关重要.
在封闭的环境中,LLPS可能会消耗自由能量,可能违反详细平衡原则 (PDB).
之前的模型表明,如果仅考虑滴滴半径作为集体坐标,PDB就会在宏观上保持.

研究的目的:

在一个封闭的环境中研究活跃的LLPS,将滴滴位置作为第二个集体坐标.
分析主动噪声对详细平衡原理的宏观影响.
探索限制潜力在活性相隔动态中的作用.

主要方法:

开发一个简单的模型,在有限的潜力范围内为活跃的LLPS开发.
将滴滴位置作为第二个集体坐标与滴滴半径一起包含.
作为诊断工具应用波动-消散定理的应用.

主要成果:

在这种模型中,活跃的LLPS在宏观层面上打破了详细平衡原则.
活动噪声不对称地抑制了线性易感性.
活动噪声还以一种不寻常的方式抑制了准临界热噪声谱.

结论:

在被限制的活跃LLPS中,当考虑多个集体坐标时,PDB的宏观违规是可能的.
活动噪声为相分离过程引入了新的,不对称的动态.
这项工作为活跃生物系统的热力学和统计力学提供了新的见解.

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