在ADAD中自我报告的运动水平和认知之间的纵向关联
Kelsey R Sewell1,2, James D Doecke3, Ralph N Martins4,5,6
1Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
定期炼与患有自体主导阿尔茨海默病 (ADAD) 突变的个体的更好的认知功能有关. 然而,与AD相关的途径可能会在认知症状出现之前减少炼参与.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 自体主导性阿尔茨海默病 (ADAD) 突变代表了研究阿尔茨海默病 (AD) 病变的独特模型.
- 了解影响ADAD突变携带者的认知因素对于开发预防策略至关重要.
研究的目的:
- 研究ADAD突变的个体中自我报告的运动和认知功能之间的纵向关系.
- 检查运动认知关联的潜在基于性别的适度.
- 为了比较ADAD突变携带者和非携带者之间的运动参与度随时间变化.
主要方法:
- 研究了491名参与者的队列,包括ADAD突变携带者和来自主导遗传阿尔茨海默症网络的非携带者.
- 参与者报告了过去12个月的平均休时间炼.
- 进行了长度认知评估.
主要成果:
- 较高的基线运动与随着时间的推移更好的认知表现有关.
- 没有观察到性别的显著适度.
- 与非携带者相比,ADAD突变携带者在症状发作前几年表现出运动参与度下降.
结论:
- 自我报告的运动与ADAD突变患者的认知功能保持有关.
- 有证据表明,与AD相关的生物学途径可能会在临床症状表现之前影响运动参与.
- 表明运动和AD风险之间存在潜在的双向关系.
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