FAdV-D血清型2的致病性在 brojler 和层中的致病性
Amr M Geneedy1, Hatem S Abd El-Hamid1, Hany F Ellakany1
1Department of Bird and Rabbit Diseases, Faculty of Veterinary Medicine, Damanhour University, El-Beheira, Egypt.
Avian pathology : journal of the W.V.P.A
|June 19, 2025
概括
禽类腺病毒D (FAdV-D) 血清型2在 brojler 和层中引起了显著的组织病理损伤, brojlers 显示出更大的易感性. 这种FAdV-D感染也显示出对的免疫抑制作用.
科学领域:
- 鸟类病理学 鸟类病理学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 在中,包容体肝炎 (IBH) 主要是由禽类腺病毒 (FAdV) 引起的.
- 了解特定FAdV血清型的病原和免疫效应对于疾病控制至关重要.
研究的目的:
- 为了研究FAdV-D血清型2分离物对肉和母的影响.
- 评估临床症状,组织病理学变化,病毒分泌和实验感染后的免疫反应.
主要方法:
- 用两种FAdV-D血清型2分离物对肉和子进行实验感染.
- 临床观察,组织病理学,病毒分泌分析 (感染后最多21天).
- 评估了血清反应 (ELISA),生化分析,先天性免疫参数 (PCR用于白细胞间蛋白/细胞因子) 和疫苗反应 (HI测试).
主要成果:
- 没有观察到死亡率,但在多个器官 (肝脏,胰腺,脏,脏,脏,胸腺,Fabricius的毛囊) 发生了显著的组织病理损伤.
- 病毒的传播持续了感染后的21天.
- FAdV-D血清型2感染增加了白血素和细胞因子,但没有诱导血清反应或影响疫苗免疫力; brojlers 比层更容易受到感染.
结论:
- FAdV-D血清型2在中引起显著的免疫抑制.
- 肉对由FAdV-D血清型2引起的IBH的易感性较高,相比于层.
- 尽管缺乏死亡率,但FAdV-D血清型2感染会诱导亚临床病理和免疫调节.
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