子轨道前皮层在基于奖励的决策过程中处理选择历史中的作用
Moegi Higuchi1, Tsuyoshi Setogawa1,2, Takuto Izawa1
1System Emotional Science, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.
过去的选择会影响决策. 轨道前皮层 (OFC) 使用选择相关因素 (HCF) 的历史来指导当前的决策,影响行为和反应时间.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 决策科学 决策科学 决策科学
背景情况:
- 决策受过去的经验和选择的影响.
- 轨道前皮层 (OFC) 在编码奖励值方面发挥着至关重要的作用.
- 以前的研究表明,OFC神经元活动是由先前的奖励结果调节的.
研究的目的:
- 调查轨道前皮层 (OFC) 如何处理过去决策中与选择相关的因素 (HCF) 的历史.
- 确定过去选择对当前决策的影响背后的神经机制.
- 阐明OFC活动在整合历史选择信息中的作用.
主要方法:
- 在决策任务期间,在子OFC中记录了神经元活动.
- 结合HCF的计算模型与没有HCF的模型进行了比较,以解释神经元活动.
- 使用肌肉醇对OFC进行药理性失活,以评估行为影响.
主要成果:
- 超过70%的OFC神经元表现出更好地通过包括HCF在内的模型来解释的活动.
- 当前选择中的神经元活动受到前一项试验中HCF的显著影响.
- 在基于HCF的试验中,选择反应时间显著不同,OFC无活化取消了这种效应.
结论:
- 选择相关因素 (HCF) 的历史显著调节轨道前皮层 (OFC) 神经活动.
- OFC的活动集成了过去的选择信息,以指导持续的决策和影响行为.
- OFC在处理选择历史中的作用有助于观察到决策中的行为偏见.
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