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光催化F-化:一种简化的放射性标记方法,用于快速采用和自动化

Yueqi Wang1, Lili Pan1, Kai Lu1

  • 1Department of Nuclear Medicine and Clinical Nuclear Medicine Research Lab, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Organic letters
|June 19, 2025
PubMed
概括

这项研究引入了一种简化的光反系统,用于快速标记-18的. 该方法避免了亚热热干燥,使研究和诊断能够有效地进行放射性标记.

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Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.