从基于PDMS的暴露概况到机器学习预测的血清度:SVOC暴露在职业和环境场景中的差异
Zihao Zhang1, Yan Wang1, Yubin Wu1
1Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. wangyandut@dlut.edu.cn.
Environmental science. Processes & impacts
|June 19, 2025
概括
垃圾处理工人和大学生面临着对半挥发性有机化合物 (SVOC) 的显著暴露. 工人暴露于酸盐 (PAE),有机酸盐 (OPE) 和多环芳 (PAH) 的风险较高,并发现了显著的癌症风险.
科学领域:
- 环境健康科学 环境健康科学
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
背景情况:
- 在不同的人群中,对半挥发性有机化合物 (SVOC) 的职业暴露尚未得到充分研究.
- 关键的SVOC包括酸盐 (PAE),有机酸 (OPE) 和多环芳 (PAH).
- 垃圾处理工人和大学生代表着不同的暴露群体.
研究的目的:
- 调查和比较废物处理工人和大学生的职业和日常SVOC暴露.
- 确定主要的SVOC来源并评估相关的健康风险,包括癌症风险.
- 用先进的建模技术预测血清度和评估暴露风险.
主要方法:
- 采用基于聚甲基 (PDMS) 的被动采样进行SVOC测量.
- 利用机器学习从环境数据中预测血清度.
- 使用蒙特卡洛模拟进行风险评估.
主要成果:
- 与学生相比,工人对PAE (2.24倍),OPE (6.87倍) 和PAH (14.9倍) 的暴露水平显著更高.
- 在学生 (37.8倍) 中,Tris{2,4-di-tert-butylphenyl) 酸盐 (TDTBPP) 的暴露显著更高.
- 对于工人来说,确定了二二乙基甲酸盐 (DEHP),甲 (BaP) 和甲 (NAP) 的显著癌症风险,而对于学生来说,则确定了DEHP.
- 预测的PAE和OPE血清度在工人和男性学生之间是可比的,但高于女性学生;PAH度在不同组中相似.
- 蒙特卡洛模拟表明,在没有保护措施的情况下,DEHP暴露的风险很高 (工人为99.7%,学生为55.0%).
结论:
- 在职业环境 (废物处理工人) 和日常环境 (学生) 之间,SVOC暴露情况有很大差异.
- 像DEHP这样的特定SVOC具有相当大的癌症风险,需要立即制定风险管理策略.
- 改善通风和减少塑化剂的使用对于减轻SVOC暴露和相关健康风险至关重要.
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