人类母乳强化与人乳强化剂与早产婴儿配方奶粉:系统性审查和元分析
Ni Nyoman Berlian Aryadevi1, Rosita Saumi Imanta Putri1, Putri Maharani Tristanita Marsubrin1,2,3
1Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Journal of neonatal-perinatal medicine
|June 19, 2025
概括
产前配方奶粉 (PTF) 强化母乳是非常低出生体重的早产婴儿人乳强化剂 (HMF) 的安全替代品,显示出类似的生长和安全结果. 这一发现是基于非常低的确定性证据.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 临床儿科 临床儿科
背景情况:
- 人类牛奶强化剂 (HMF) 的有限可用性和高成本在发展中国家构成了挑战.
- 作为母乳强化剂的早产婴儿配方 (PTF) 是一个潜在的替代品,但其安全性和生长影响需要研究.
研究的目的:
- 为了比较PTF强化母乳与HMF强化母乳在非常低出生体重的早产婴儿的安全性和生长效应.
主要方法:
- 在 2024 年 3 月 24 日之前,对多个数据库进行系统的文献搜索.
- 将随机对照试验 (RCT) 纳入使用Cochrane Risk of Bias 2工具进行质量评估.
- 使用GRADE的统计分析和证据评估的确定性.
主要成果:
- 分析了6项涉及434名婴儿的RCT.
- 在PTF和HMF组之间,在体重增加,长度或头部周长方面没有发现显著差异.
- 在两种强化方法之间观察到可比的发病风险.
结论:
- 非常低的确定性证据表明PTF是HMF的安全替代品,用于母乳强化.
- 与HMF相比,PTF在早产婴儿中表现出类似的安全概况和生长效应.
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