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Updated: Sep 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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一个p53-准小分子的机械洞察力

Ricardo J F Ferreira1, Valentina Barcherini1, Catarina Roma-Rodrigues2,3,4

  • 1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal.

ACS pharmacology & translational science
|June 19, 2025
PubMed
概括

一种新型化合物RVJB59有效地重新激活了癌细胞中的p53通路. 它在临床前模型中表现出低清除率,选择性结合p53和抗癌作用.

关键词:
癌症 癌症 癌症 癌症 癌症半氨酸 (cysteine) 是一种氨酸.这种类型的物质是isoindolinones.在p53中,p53是什么?蛋白质修饰是一种蛋白质修饰.

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