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在结性脊柱炎中与疼痛和抑郁相关的区域同质性变化:功能磁共振成像研究

Kelei Hua¹, Peijun Wang², Bin Xia¹

¹Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.

Frontiers in neurology

|June 19, 2025

概括

结性脊柱炎患者在与疼痛和抑郁症相关的区域显示出大脑活动的改变. 了解这些神经模式可能有助于为患有情绪障碍的AS患者个性化治疗.

科学领域:

神经成像是一种神经成像.
医学研究医学研究
精神病学是一个精神病学.

背景情况:

结性脊柱炎 (AS) 经常与由于慢性疼痛而导致的抑郁症同时发生.
连接AS疼痛和抑郁症的潜在神经机制尚未得到充分理解.
与AS相关的抑郁症的有效治疗策略的开发具有挑战性.

研究的目的:

研究与AS患者疼痛和抑郁相关的区域同质性 (ReHo) 改变.
探索ReHo变化与AS患者疼痛和抑郁症的临床测量之间的关系.

主要方法:

招募了43名AS患者和46名年龄/性别匹配的健康对照.
使用临床尺度 (BASDAI,TBP,HAMD) 和炎症标志物评估患者.
使用3TMRI来比较ReHo组之间的差异和分析的相关性.

主要成果:

在AS患者中,左上旋和右偏中心叶片的ReHo下降.
在AS患者的左前和右中前环中观察到ReHo的增加.
左前 ReHo与疼痛和抑郁症得分有负相关性;右半中心叶 ReHo与AS持续时间和疼痛相关.

结论:

这项研究提供了对AS疼痛和抑郁症背后的大脑过程的新见解.
特定大脑区域的改变ReHo可能会导致AS的感觉,情绪和处理问题.
根据这些神经相关物来识别患者可以实现量身定制的治疗干预措施.

关键词:

结性脊柱炎是一种疾病.抑郁抑郁症抑郁症抑郁症抑郁症功能磁力共振成像 (fMRI) 是一种疼痛疼痛疼痛疼痛区域均性区域均性

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