昼夜节律基因中的多态性和差异化甲状腺癌的风险
Takiy-Eddine Berrandou1,2, Emilie Cordina-Duverger1, Claire Mulot3
1University Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Team "Exposome and Heredity", Villejuif, France.
Frontiers in genetics
|June 19, 2025
概括
循环基因变异不会直接增加差异化甲状腺癌 (DTC) 的风险. 然而,吸烟可能会改变这些基因变化和DTC发展之间的关系.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 昼夜节律由昼夜基因调节,影响细胞增殖,细胞周期和细胞亡.
- 昼夜基因中的多态性被研究为它们在差异化甲状腺癌 (DTC) 风险中的潜在作用.
研究的目的:
- 为了检查昼夜基因多态和DTC风险之间的关联.
- 调查这些多形态和已知的DTC风险因素,特别是吸烟之间的潜在相互作用.
主要方法:
- 一个病例控制研究涉及463个DTC病例和482个欧洲血统的控制.
- 在23个昼夜基因中使用多变量逻辑回归分析了570个单核酸多态 (SNP).
- 基因和通路水平的关联以及基因与环境的相互作用,使用适应性排序截断产品 (ARTP) 方法进行评估.
主要成果:
- 在SNP,基因或通路水平上,没有发现DTC风险和昼夜基因多态性之间有显著的直接关联.
- 在吸烟状态和特定SNP之间观察到显著的相互作用 (RS11204897在RORC中,RS1012477在PER3).
- 还注意到PER3基因,整体昼夜通路和吸烟状态之间的相互作用.
结论:
- 单单循环基因多态性似乎不是DTC的重要危险因素.
- 吸烟状态可能会改变昼夜基因变异对DTC风险的影响.
- 需要进一步的研究来验证这些基因环境相互作用在更大的队列.
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