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美国老年人的维生素C摄入量和认知功能:非线性剂量反应关联以及吸烟状态对效果的改变
Xingchen He1, Yijia Lin1, Xinyi Wu1
1The Affiliated Guangzhou Hospital of TCM of Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in nutrition
|June 19, 2025
概括
更高的维生素C摄入量与老年人的更好的认知功能有关,尤其是吸烟者. 在特定摄入水平下观察到对记忆和处理速度的最佳益处,这表明有针对性的补充.
科学领域:
- 营养科学 营养科学
- 老年学是指老年学的学科.
- 认知神经科学 认知神经科学
背景情况:
- 认知能力下降是老年人群的一个重大问题.
- 维生素C (酸) 是一种重要的抗氧化剂,具有潜在的神经保护作用.
- 了解维生素C摄入量与认知功能之间的关系对于公共健康至关重要.
研究的目的:
- 为了检查维生素C摄入量与美国老年人的认知功能之间的关联.
- 通过子组确定剂量-反应关系和效果修改.
- 为了告知潜在的营养策略,在衰老的认知健康.
主要方法:
- 来自NHANES (2011-2014) 的2,801名60岁以上的美国成年人的横截面分析.
- 通过24小时饮食回忆和补充剂使用评估总维生素C摄入量.
- 使用CERAD单词学习,动物流利性测试 (AFT) 和数字符号替换测试 (DSST) 的认知功能评估.
- 统计建模包括多变量回归,平滑曲线拟合和分层分析.
主要成果:
- 在维生素C摄入量和认知表现之间观察到非线性剂量反应关系.
- 与最低四分位数 (Q1) 相比,较高的维生素C摄入量 (Q4) 与在AFT和DSST上显著更好的表现有关.
- DSST的认知益处达到500毫克/天的峰值,而AFT的益处在120毫克/天的平原.
- 维生素C的认知效益在吸烟者中更为明显,而在非吸烟者中没有显著的关联.
结论:
- 维生素C摄入量与美国老年人的认知功能改善有关.
- 对于认知益处,存在明显的剂量依赖和域特定的值效应.
- 吸烟状态显著改变了这一关联,突出了吸烟者向补充剂的潜力,以增强认知保护.
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