通过皮肤注射乙醇和酸治疗甲状腺功能障碍症 - - 一个单一中心的经验
Eugene Kwong Fei Leong1,2, Ray Meng See2, Zhimin Lin1,3
1Division of General Surgery (Endocrine & Thyroid Surgery), Department of Surgery, National University Hospital, Singapore, Singapore.
Frontiers in endocrinology
|June 19, 2025
概括
通过皮肤注射乙醇和酸盐可提供可行的,安全的替代方案,以手术治疗甲状腺功能障碍 (HPT). 虽然对门诊治疗有希望,但需要进一步的研究来证实疗效和成本效益.
科学领域:
- 内分泌学 在内分泌学.
- 最少侵入性手术的方法
背景情况:
- 甲状腺功能障碍症 (HPT) 管理通常涉及手术性甲状腺功能障碍切除术.
- 医疗治疗可能是耐火的,需要替代治疗策略.
研究的目的:
- 评估HPT的皮肤内乙醇注射疗法 (PEIT) 和皮肤内醇注射疗法 (PCIT).
- 评估这些作为外科手术的门诊替代品的有效性,安全性和可行性.
主要方法:
- 在2018年1月至2021年12月期间,九名HPT患者接受了PEIT或PCIT.
- 随访持续时间平均为9.0个月,分析了血清标志物 (iPTH,Ca,性酸酶,维生素D) 和患者人口统计数据.
主要成果:
- PEIT: 4名患者中有2名成功治疗; 1名患者需要用cinacalcet治疗持续性高热血症.
- PCIT:在5名患者中,有3名患者的手术成功;有1名患者患有耐药性疾病.
- 在这个群体中,PEIT和PCIT都是可行的和安全的.
结论:
- 穿皮注射疗法 (PEIT和PCIT) 是可行的和安全的替代方案,用于医疗耐火的HPT.
- 与手术相比,这些门诊手术可能会降低成本.
- 在广泛采用之前,需要进行进一步的研究来确定最终的疗效和成本效益.
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