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免疫检查点抑制剂诱导的甲状腺炎及其潜在机制

Xueqian Mao¹, Chaoming Mao¹, Jiameng Liu¹

¹Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Frontiers in endocrinology

|June 19, 2025

概括

免疫检查点抑制剂 (ICI) 可以导致甲状腺功能障碍,一个显著的免疫相关不良事件 (irAE). 了解ICI诱导的甲状腺炎机制对于改善癌症免疫治疗结果至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
甲状腺功能障碍是与ICI相关的常见免疫相关不良事件 (irAE).
了解ICI诱导的甲状腺炎的机制对于患者管理至关重要.

研究的目的:

系统地审查目前对ICI诱导甲状腺炎的病原发生的理解.
探索ICI的药理学方面及其在甲状腺自身免疫性中的作用.
分析ICI治疗后导致甲状腺功能障碍的细胞和分子因素.

主要方法:

综合文献综述. 这是一个全面的文献综述.
药理学性质的ICI. 的药理学特征.
细胞和分子贡献者的多因素分析.
对病原性假设的批判性评价.

主要成果:

ICI治疗可以导致显著的甲状腺功能障碍.
多种细胞和分子通路有助于ICI诱导的甲状腺自身免疫.
新兴的假设揭示了主要的致病驱动因素.

结论:

对ICI诱导的甲状腺炎的机制性见解正在进步.
建立ICI药理学和甲状腺免疫病理学之间的联系是关键.
进一步的研究将有助于开发ICI相关甲状腺功能障碍的诊断和治疗策略.

关键词:

甲状腺功能低下症甲状腺功能低下症免疫检查点抑制剂诱导的甲状腺炎免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.甲状腺毒素的发生

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