铁缺乏性贫血和氧化应激在2型糖尿病患者在美特福林治疗:一个元分析
Arooba Rubbani1, Danial Khalid2, Savera Nadeem3
1Medicine, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Cureus
|June 19, 2025
概括
接受甲福明治疗的2型糖尿病患者的缺铁性贫血 (IDA) 与氧化应激增加有关. 这表明对这些患者进行贫血和氧化应激查至关重要.
科学领域:
- 内分泌学和新陈代谢学
- 血液学 血液学 血液学
- 营养科学 营养科学
背景情况:
- 缺铁性贫血 (IDA) 是一种普遍存在的全球营养障碍.
- 2型糖尿病 (T2DM) 患者经常患上IDA.
- 甲福明是T2DM的一线药物,可能会导致缺铁并加剧氧化应激.
研究的目的:
- 为了评估IDA和氧化应激之间的关联在T2DM患者治疗美特福林.
- 探索甲胺对糖尿病患者血液状况和氧化应激的影响.
主要方法:
- 对2000年1月至2024年3月期间发表的研究进行了元分析.
- 在PubMed,CENTRAL,Scopus,ProQuest和谷歌学者中进行系统搜索.
- 包括研究报告铁指数和氧化应激标志物在T2DM患者在甲胺.
主要成果:
- 包括3项研究,521名参与者.
- 接受甲福明治疗的患者具有显着较低的血红蛋白水平 (11.6 g/dL vs 13.8 g/dL).
- 在IDA患者中观察到氧化应激标志物 (MDA) 的升高和抗氧化剂水平的降低 (SOD,GSH,GPx). 较高的HbA1c和较长的糖尿病持续时间与较差的氧化参数相关.
结论:
- 接受甲福明治疗的T2DM患者的IDA显著与增加的氧化应激和减少的抗氧化能力有关.
- 建议在接受甲福林治疗的糖尿病患者进行贫血和氧化应激标志物的常规查.
- 需要进一步的研究来指导长期治疗策略来管理这些相互关联的疾病.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Oral Hypoglycemic Agents: Biguanides and Glitazones
310
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
310
Psychoneuroimmunology: Diabetes and Cancer
67
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
67
Carbohydrate Metabolism
11.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.8K
Diabetes Mellitus: Overview and Type I Subtype
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K


