嗅觉功能障碍的病毒病因和组织病理特征:系统性审查
Kimia Motlagh Asghari1, Nasim Kakavand2, Mahdieh Taiyeb Khosroshahi3
1Physical Medicine and Rehabilitation Research Center Tabriz University of Medical Sciences Tabriz Iran.
Health science reports
|June 19, 2025
概括
像COVID-19这样的病毒感染后的永久性嗅觉功能障碍涉及鼻腔组织损伤和炎症. 了解这些组织病理变化是开发有效治疗气味丧失的关键.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 包括SARS-CoV-2在内的病毒感染与嗅觉功能障碍有关.
- 永久性气味丧失需要了解其病毒原因和组织病理特征.
- 优化诊断和治疗需要洞察后病毒嗅觉障碍机制.
研究的目的:
- 系统地审查和综合病毒引起的永久性嗅觉功能障碍的组织病理学特征的证据.
- 阐明潜在的机制,重点关注病毒损伤,炎症和血管变化.
- 识别有关嗅觉功能障碍病毒病因的当前研究中的差距.
主要方法:
- 按照PRISMA指南进行系统审查,在PROSPERO.中注册.
- 在主要科学数据库中进行的搜索截至2024年2月.
- 包括对患有永久性病毒诱导的嗅觉功能障碍的人类实验的观察性研究;使用既有工具进行质量评估.
主要成果:
- 八项研究符合纳入标准,其中SARS-CoV-2和普通感冒病毒作为主要病因.
- 组织病理学揭示了粘膜缩,炎症和神经上皮退化.
- SARS-CoV-2 感染显示出特定的神经上皮和内皮病理影响嗅觉.
结论:
- 病毒引起的永久性嗅觉功能障碍是复杂的组织病理变化的结果,包括神经侵袭和炎症.
- 了解这些机制对于有针对性的干预和管理长期嗅觉后果至关重要.
- 除了SARS-CoV-2之外,还需要对病毒病因进行进一步的研究,目前这些病毒病因尚未得到充分研究.
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