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Updated: Sep 19, 2025

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辐射引起的损伤和肠道微生物群:从微生物角度的见解
Qiaoli Wang1, Guoqiang Xu2, Ouying Yan1
1Department of Radiation Oncology/Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Therapeutic advances in gastroenterology
|June 19, 2025
概括
辐射损伤,如急性辐射肠炎,可以通过了解肠道微生物群来减轻. 本综述探讨了直接和间接的相互作用和干预措施,如益生菌,以改善癌症放射治疗.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 放射治疗是一种关键的癌症治疗方法,但辐射损伤,特别是急性辐射肠炎影响80%的腹盆患者,限制了其使用.
- 缺乏辐射肠炎的有效缓解策略,阻碍了放射治疗的临床应用.
- 肠道微生物群正在成为辐射损伤的潜在生物标志物,但其相互作用机制尚不清楚.
研究的目的:
- 审查肠道微生物群与辐射损伤之间的复杂相互作用.
- 阐明肠道微生物群参与辐射引起的损害的直接和间接机制.
- 总结针对肠道微生物群的当前和潜在干预措施,以减轻辐射伤害.
主要方法:
- 文献综述总结了有关肠道微生物群和辐射损伤的现有研究.
- 相互作用的分类为直接 (肠道) 和间接 (系统轴) 影响.
- 分析微生物群调节干预措施,如益生菌,益生菌和便微生物群移植.
主要成果:
- 直接相互作用涉及肠道微生物组成,代谢物,肠道屏障功能和宿主免疫反应的改变.
- 间接相互作用突出显示了肠道微生物群对肠-大脑,肠-心肺和肠-口腔轴的影响.
- 诸如益生菌,益生菌和便微生物群移植等干预措施对调节肠道微生物群以缓解辐射损伤有希望.
结论:
- 肠道微生物群和辐射伤害之间的相互作用是复杂而多方面的.
- 对潜在机制的进一步研究对于开发有效的基于微生物群的策略至关重要.
- 了解这些相互作用可以改善预防和减轻辐射引起的损伤,提高放射治疗结果.
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