在牙周治疗中使用抗生素:总体审查
João Botelho1, Patrícia Lyra1, Gustavo G Nascimento2,3
1Egas Moniz Center for Interdisciplinary Research, Egas Moniz School of Health and Science, Almada, Portugal.
Frontiers in cellular and infection microbiology
|June 19, 2025
概括
这一综合性审查发现没有强有力的证据支持在牙周治疗中使用抗生素. 系统性抗生素对牙周炎的益处很小,进一步的研究不太可能改变这一结论.
科学领域:
- 牙周病学 牙周病学
- 基于证据的牙科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌药物管理强调适当使用抗生素.
- 在牙周病学中使用抗生素治疗已被广泛研究.
- 系统审查 (SRs) 对于评估证据质量至关重要.
研究的目的:
- 评估在牙周治疗中对全身和局部抗生素的SR的方法质量.
- 评估现有证据的元分析强度和有效性.
- 为了确定在牙周病的抗生素使用的整体稳定性.
主要方法:
- 一个广泛的文献搜索确定了SRs到2024年3月.
- 用A MeaSurement工具来评估系统性审查2 (AMSTAR 2) 评估SR的方法质量.
- 防故障数分析探讨了未发表或缺失的研究的潜在影响.
主要成果:
- 包括44个SR,包括221个元分析.
- 总体上,SRs的方法质量主要是低的.
- 虽然一些元分析表明抗生素具有有益作用,但证据通常基于低质量的评论或显示微不足道的临床意义.
结论:
- 缺乏强有力的证据来支持在牙周治疗中常规使用抗生素.
- 系统性抗生素对牙周炎结果的影响很小.
- 未来的研究不太可能显著改变当前关于抗生素在牙周病的疗效的证据水平.
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