在晚年抑郁症中,与危险饮酒相关的结构性大脑变化
David C Steffens1, Lihong Wang1, Kevin J Manning1
1Department of Psychiatry (DCS, LW, KJM), University of Connecticut School of Medicine, Farmington CT; Departments of Psychiatry and Neuroscience (GDP), Yale University School of Medicine, New Haven CT; and the Olin Neuropsychiatry Research Center (GDP), Institute of Living, Hartford, CT.
概括
患有抑郁症的老年人风险饮酒与大脑结构变化有关,特别是在额头区域. 随着时间的推移,减少酒精消费与积极的大脑体积变化相关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 在患有抑郁症的老年人中,酒精使用很普遍.
- 了解酒精消费对这一人口群体大脑结构的影响至关重要.
研究的目的:
- 在患有抑郁症的老年人中,评估两年内大脑结构变化.
- 为了检查酒精消费和大脑结构变化之间的关联.
主要方法:
- 一项纵向队列研究,涉及58名60岁以上的成年人,他们有重大抑郁症发作.
- 基线和2年后的结构性MRI扫描,以及对酒精消耗和认知功能的评估.
主要成果:
- 与中度饮酒者相比,冒险饮酒者 (>7杯/周) 的皮质厚度较薄,额头区域的体积较小.
- 每年大脑体积的变化与每周饮酒量的变化有负相关性.
- 抑郁症,认知和减少酒精摄入量的改善与大脑体积变化有关.
结论:
- 酒精使用对抑郁症的老年人中前-上回路产生不利影响.
- 强调在这个人群中查和治疗风险性酒精使用的重要性.
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