身体活动和常见的妇科病症之间的因果关系:一个双样本的门德尔随机化研究
Mengyu Fu1, Xiaoyue Zhu2, Jie Chen1
1Institute for Fetology & Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, P. R. China.
American journal of translational research
|June 19, 2025
概括
身体活动 (PA) 显示对妇科疾病的因果关系. 像步行和体育运动这样的特定炼可以降低某些癌症和疾病的风险,而久坐不动的行为会增加这些风险.
科学领域:
- 遗传学和流行病学
- 妇女健康研究 妇女健康研究
背景情况:
- 流行病学研究表明,身体活动 (PA) 与妇科病理之间存在联系.
- 在PA模式和妇科疾病之间的因果关系需要进一步调查.
研究的目的:
- 使用孟德尔随机化 (MR) 评估各种体育活动表型和妇科疾病之间的因果关系.
- 确定影响不同妇科疾病风险的特定PA类型.
主要方法:
- 采用孟德尔随机化 (MR) 使用欧洲祖先女性全基因组关联研究 (GWAS) 数据.
- 分析了八种妇科疾病和四种PA仪器.
- 使用反变量加权 (IVW) 估计,并补充了灵敏度分析 (MR-Egger,加权中位数,MR-PRESSO) 以确保稳定性和解决潜在的变性.
主要成果:
- 特定的运动 (步行,强度运动,其他运动) 与ER阳性乳腺癌 (BC),子宫内膜癌 (EC) 和子宫内膜异位症 (ES) 的风险降低有关.
- 久坐不动的屏幕时间增加与ER阳性BC和卵巢囊 (OCS) 的更高风险有关.
- 对多囊性卵巢综合征 (PCOS) 与步行和剧烈运动观察到矛盾的关联;对于宫癌 (CC),卵巢癌 (OC) 或子宫纤维瘤 (UF) 没有发现因果关系.
结论:
- 这项MR研究为PA对妇科疾病的差异性因果作用提供了新的证据.
- 对ER阳性BC,EC和ES观察到运动模式特有的保护作用.
- 结果强调PA是女性健康的可修改因素,表明需要量身定制的运动指南.
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