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骨髓介质干细胞与肝细胞生长因子结合在亚急性声伤口愈合上的新应用

En-Hong Xu^1,2,3, Xin-Jun Meng¹, Tian-Yu Wang³

¹Department of Otolaryngology Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Shanghai China.

World journal of otorhinolaryngology - head and neck surgery

|June 19, 2025

概括

带有肝细胞生长因子 (HGF) 的骨髓介质干细胞 (BMMSC) 显示了声 (VF) 痕的再生潜力. 这种组合疗法在亚急性VF伤口中降低了原水平,这表明了声再生的新治疗方法.

科学领域:

再生医学是一种再生医学.
耳鼻喉科耳鼻喉科耳鼻喉科
干细胞疗法是一种干细胞疗法.

背景情况:

由于受伤或手术造成的声 (VF) 痕导致了严重的声音问题.
目前对VF痕的治疗方法有限,特别是在亚急性阶段.
对VF伤口愈合的亚急性时期的干预措施的研究很少.

研究的目的:

研究结合骨髓介质干细胞 (BMMSCs) 与肝细胞生长因子 (HGF) 对声粘膜再生的影响.
评估BMMSCs-HGF治疗在声损伤的亚急性阶段的疗效.

主要方法:

在新西兰白中创建了双边声伤口.
骨髓介质干细胞 (BMMSC) 与无细胞皮肤基质作为细胞载体一起使用.
在受伤后2或4周内,BMMSCs与HGF结合或不结合被注射到声伤口.
组织分析包括传输电子显微镜 (TEM) 和免疫组织化学 (IHC) 分析.

主要成果:

免疫组织化学分析显示,BMMSCs-HGF组的I型原蛋白水平明显低于BMMSCs-only组.
传输电子显微镜的结果表明,BMMSCs-HGF注射显著降低了原分数.
这项研究涉及18只子,其中16只完成了干预阶段.

结论:

BMMSCs和HGF的组合显示出对亚急性声痕的有前途的再生效果.
这项初步研究表明,使用BMMSCs-HGF改善声再生的潜在治疗策略.

关键词:

骨髓中介细胞干细胞骨髓中介细胞干细胞细胞外矩阵是细胞外矩阵.肝细胞生长因子肝细胞生长因子语音伤口愈合伤口愈合

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