探索传统中医治疗双相情感障碍的模式:一个数据驱动的网络方法
Zhenshan Sun1,2, Jiangbangrui Chu1,2, Junjie Peng3
1Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
Frontiers in pharmacology
|June 19, 2025
概括
传统中医提供双相情感障碍的补充治疗方法. 这项研究确定了五种关键的草药及其活性代谢物,揭示了涉及GABA-A受体和ESR1的机制,用于潜在的治疗开发.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 传统中医 (TCM) 提出了一种全面的方法来治疗双相情感障碍 (BD).
- 在TCM中分散的临床数据给翻译研究带来了挑战.
- 数据挖掘方法可以揭示TCM治疗模式和代谢物相互作用.
研究的目的:
- 确定用于治疗双相情感障碍的TCM中使用的核心植物药物和活性代谢物.
- 阐明这些TCM治疗的潜在作用机制.
- 建立数据驱动研究的基础,将TCM与BD疗法整合在一起.
主要方法:
- 使用DisGeNET和GeneCards用于BD目标,以及BATMAN-TCM2.0用于植物药物.
- 使用Cytoscape和Python构建了植物药物代谢物目标网络.
- 在SH-SY5Y细胞上进行了体外研究,使用MTT活力测定和qRT-PCR.
主要成果:
- 确定了五种关键的植物药物:糖树根 Et Rhizoma,Poria,Coptidis Rhizoma,Bupleuri Radix和多树根.
- 棕酸和酸对细胞活力和基因表达有剂量依赖的影响.
- 这些代谢物双向调节了GABRA1和ESR1的表达.
结论:
- 在TCM中,五种核心植物药物被确定用于治疗双相情感障碍.
- 主要机制涉及对胺酸甲型受体和ESR1.1的调节.
- 这项研究提供了关于TCM在双相情感障碍管理中的作用的见解.
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