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在患有复发性复发性多发性硬化症患者中,认知与残疾和身体表现的相关性

Marko Luostarinen¹, Anne M Portaankorva^2,3,4, Pirjo Urpilainen¹

¹Institute of Biomedicine, Sports and Exercise Medicine, University of Eastern Finland, Kuopio, Finland.

Journal of central nervous system disease

|June 19, 2025

概括

通过六分钟步行测试测量的身体活动与多发性硬化症 (MS) 患者的认知功能和残疾有关. 更好的行走表现预测了MS患者的认知能力改善和残疾减少.

科学领域:

神经学神经学
康复医学康复医学康复医学
神经科学是一个神经科学.

背景情况:

认知障碍是多发性硬化症 (MS) 的一个普遍问题.
众所周知,体力活动会影响MS患者的认知表现.
常规认知测试尚未成为MS临床实践中的标准.

研究的目的:

检查复发性复发性多发性硬化 (RRMS) 患者的认知功能,身体残疾和身体表现之间的关系.
了解身体活动和残疾水平如何与RRMS中的认知能力相关.

主要方法:

41名RRMS患者 (扩展残疾状况尺度0-5.5) 和20名对照人接受了MS功能复合 (MSFC) 和符号数字模式测试 (SDMT).
测量了6分钟步行 (6MW) 距离,加速度计跟踪了7天的日常活动.
统计分析探讨了认知测试,残疾分数 (EDSS) 和身体表现指标之间的相关性.

主要成果:

在RRMS患者的认知 (MSFC/SDMT) 和残疾 (EDSS/6MW) 之间观察到显著的相关性.
认知功能 (SDMT) 在EDSS>2.5的患者中明显较差,与EDSS ≤2.5或对照组患者相比.
在残疾较高 (EDSS高) 的患者中,更好的6MW性能与优异的SDMT结果相关.

结论:

在MS中,残疾,身体表现 (6MW) 和认知功能之间存在着强烈的关联.
在6MW测试中提高性能可以预测MS患者更好的认知结果和更低的残疾水平.
临床试验注册:NCT04115930.0. 临床试验注册:NCT04115930. 临床试验注册:NCT04115930. 临床试验注册:NCT04115930.

关键词:

6分钟的步行测试测试加速度计的加速计是什么?认知认知认知身体残疾就是残疾.多发性硬化症多发性硬化症身体活动身体活动

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