L-卡尼丁可降低头癌中化学放射疗法诱导的毒性:一项随机研究
Kumari Puja1, Kamna Singh2, Indira Yadav3
1Department of Radiotherapy, All India Institute of Medical Sciences, Deoghar, India.
Head & neck
|June 19, 2025
概括
补充L-carnitine可能会减少头癌患者接受化学辐射治疗的治疗毒性. 这种干预措施改善了生活质量,减少了住院病例,但并没有影响治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 营养支持营养支持
背景情况:
- 癌症治疗中的毒性会严重损害患者的生活质量,并可能导致治疗中断.
- 减少与治疗相关的副作用对于维持治疗疗效和改善患者治疗结果至关重要.
研究的目的:
- 评估L-carnitine在减轻与头部和部状细胞癌 (HNSCC) 患者同时化学辐射相关的毒性方面的疗效.
- 评估L-卡尼丁在HNSCC治疗期间对营养状况,疲劳和生活质量的影响.
主要方法:
- 一个随机对照试验,涉及HNSCC患者同时接受化疗辐射.
- 研究组接受了口服L-卡尼丁 (每天500毫克三次) 以及标准护理,而对照组仅接受了标准护理.
- 毒性,营养状况 (血红蛋白,白蛋白,体重),疲劳 (简要疲劳库存),生活质量 (EORTC-QLQ-C30) 和治疗反应 (RECIST 1.1) 都被评估.
主要成果:
- 甲氨酸显著降低了皮肤炎,粘膜炎,喉反应和消化不良的严重程度,并延迟了皮肤炎,粘膜炎,喉反应和消化不良的出现.
- 接受L-carnitine治疗的患者显示治疗后疲劳得分显著降低,白蛋白水平更好.
- 与对照组相比,L-卡尼丁组的中位体重减轻较低,并且住院病例显著减少.
结论:
- 补充L-carnitine似乎是一种有益的干预措施,用于减少同时接受化疗辐射的HNSCC患者的治疗相关毒性.
- 进一步的大规模,多中心随机试验是有必要的,以证实这些发现,并建立L-carnitine作为标准的支持性护理措施.
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