基胺对前前带带皮层的功能连接性改变以及拉莫特里金对其调节
David Weigner1,2, Marvin Sören Meiering1,2, Anne Weigand1
1Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
Journal of psychopharmacology (Oxford, England)
|June 19, 2025
概括
胺可以通过影响谷氨酸释放来增强精神病患者的大脑连接. 一种谷氨酸酸抑制剂拉莫特里金 (lamotrigine) 阻断了这些效应,这表明谷氨酸是胺酸的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 亚麻醉类胺在慢性压力病理 (CSP) 的精神病症中表现有前途.
- 前前环皮质 (pgACC) 的功能连接 (FC) 发生变化与胺的作用有关.
- 谷氨酸在胺诱导的FC变化中的作用及其对工作记忆 (WM) 的影响需要进一步研究.
研究的目的:
- 调查胺和拉莫特里金对pgACC FC的急性和持续作用.
- 在休息状态和工作记忆 (WM) 任务中检查FC.
- 探索谷氨酸传递在调解胺对神经网络影响中的作用.
主要方法:
- 这是一项双盲,安慰剂控制,随机的研究,涉及75名健康参与者.
- 功能性磁共振成像 (fMRI) 在基线时,在基因素服用期间和基因素服用后24小时采集.
- 参与者接受了胺,胺与拉莫特林或安慰剂;pgACC FC使用Julich大脑图谱面具进行分析.
主要成果:
- 在WM任务中,胺显著增加了pgACC FC与背中介前额叶皮质的作用.
- 胺增强的静止状态FC在pgACC和左侧胰岛之间.
- 拉莫特里金的预处理取消了这些胺诱导的FC增强.
结论:
- 胺对神经网络的有益影响很可能是由谷氨酸释放的介导.
- 这项研究支持了将谷氨酸传输与胺管理后增强的FC联系在一起的假设.
- 向谷氨酸通路可能是治疗CSP相关精神疾病的可行策略.
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