通过含有N,N-DMT和harmine的雅华斯卡灵感配方增强正念和同情:健康受试者的随机对照试验
Helena D Aicher1,2,3, Ilhui A Wicki1, Daniel Meling1,4
1Psychedelic Research and Therapy Development, Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Journal of psychopharmacology (Oxford, England)
|June 19, 2025
概括
一种DMT/harmine配方在健康受试者中急剧增强了正念和同情心,表明了治疗潜力. 这种迷幻体验可能为改善幸福感提供了传统冥想实践的替代方案.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 正念和同情是治疗上重要的特征,通常通过冥想来培养.
- 冥想需要时间和承诺,这对情绪障碍的人来说可能是个挑战.
- 需要替代方法来增强正念和同情心.
研究的目的:
- 研究一种迷幻的N,N-二甲基三胺 (DMT) /harmine配方对正念和同情的影响.
- 探索这种DMT/harmine配方的潜在治疗应用.
主要方法:
- 一个随机的,双盲的,安慰剂控制的,在受试者内部的设计被采用了31名健康参与者.
- 参与者在三个会议中接受了DMT/harmine配方,与安慰剂一起服用,或单独服用安慰剂.
- 正念 (MINDSENS) 和同情 (SOCS) 被评估为主要结局.
主要成果:
- 治疗后一天,DMT/harmine配方显著增加了正念,自我同情和对他人的同情.
- 在高敏感度和低敏感度组之间观察到正念和同情心的显著差异.
- 该药物对所有测量结果都表现出显著的影响.
结论:
- 这种DMT/harmine配方显示了急性增强正念和同情的潜力,类似于植物性亚亚瓦斯卡.
- 研究结果表明,这种配方可能对正念和同情有益的条件提供治疗效益.
- 需要在临床环境中进行进一步的研究,以了解作用机制.
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