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对合成和天然聚合物的碳水化合物结合模块的结合特异性的高通量调查

Andrew Philip Rennison1, Jaime Fernandez-Macgregor2, Julie Melot2

  • 1Department of Biotechnology and Biomedicine, The Technical University of Denmark, Søltofts Plads, Building 221, DK-2800, Kgs. Lyngby, Denmark.

ChemSusChem
|June 19, 2025
PubMed
概括

研究人员选了近800个碳水化合物结合模块 (CBM),以检测它们与PET等合成塑料结合的能力. 这项工作确定了塑料降解的新CBM,并提高了酶性能,帮助解决塑料污染问题.

关键词:
高通量选的高通量选塑料废物降解降解塑料废物降解蛋白质与基质的相互作用

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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...